In a MDPI Journal Life paper, Alexandra Proshchina and a team* of Russian researchers summarize the research that has been performed thus far on reproduction of invertebrates in space. As mentioned in the article, the only data we have on mammalian reproduction in microgravity since the dawn of the space age is from two experiments carried out over 26 years ago. The studies looked at pregnant rats launched aboard the Space Shuttle on missions STS-66 and STS-70 in 1994 and 1995 respectively, and there have never been any births of mammals in space. This huge knowledge gap on reproduction in space is problematic for human space settlement. Yet Elon Musk, The Mars Society, and other groups are charging ahead with plans for cities on Mars. What if we discover that humans cannot have healthy babies in 0.38g? SSP has covered the quest for determining the gravity prescription before looking at JAXA’s effort to at least start experimenting with artificial gravity in space, albeit on adult mammals (mice). We are still waiting for JAXA’s published results of 1/6g experiments carried out in 2019.
The data from the Space Shuttle program only looked at part of the gestation period (after 9 days) and only in microgravity. The results did not bode well for reproduction in space. Some findings “…clearly indicate that microgravity, and possibly other nonspecific effects of spaceflight, can alter the normal development of the brain itself.”
So we have this one piece of data for reproduction in microgravity and nothing in higher gravitational fields except what we know here on Earth in 1g.
Would partial gravity like on the Moon or Mars be sufficient for normal fetal development in rats (or mammals in general, especially humans) during the full gestation period? If problems are identified could it be extrapolated to human reproduction? The fact that homo sapiens and their ancestors evolved on Earth in 1g for hundreds of thousands of years is a big red flag for future space colonists that hope to settle on the surface of planetary bodies and have children.
We don’t know how lower gravity conditions could affect embryonic cell growth. How would the changes in surface tension and embryo cell adhesion be altered in these environments? We have very little data on cellular mechanisms and embryonic alterations that lower gravity may induce that could affect fetal development.
“There are also many other questions to be answered about vertebrate development under space flight conditions.”
A recent report on giving birth in space by SpaceTech Analytics looks at many of the factors that need to be considered for human reproduction off Earth. Most problems could be potentially mitigated through engineering solutions such as radiation protection, medical innovations tailored for space use, life support technology, etc. In this entire presentation the authors gave very little consideration to partial gravity affects on human embryos and child birth. One slide (number 70) out of 85 discusses these issues.
It is clear that more and longer term experiments will be necessary to determine how partial gravity affects the reproduction and development of mammals before humans settle space. Some researchers are actually considering genetic modification to allow healthy reproduction in space, and the ethical considerations associated with this course of action. Obviously, such a drastic methods would come only if there was no other alternative. One would think that building O’Neill type habitats rotating to produce 1g of artificial gravity would be preferable to such extreme measures.
Clearly, we need a space based artificial gravity laboratory to carry out ethical clinical studies on the gravity prescription for human reproduction, starting with rodents and other lower organisms. SSP recently covered a kilometer long version of such a facility that could be deployed in a single Falcon Heavy launch. And don’t forget Joe Carroll’s proposal for a LEO partial gravity test facility. Doesn’t it make sense to invest in such a facility and do the proper research before (or at least in parallel to) detailed engineering studies of colonies on the Moon or Mars intended for long term settlement? This research could inform decision making on where we will eventually establish permanent space settlements: on the surface of smaller worlds or in free space settlements envisioned by Gerard K. O’Neill. Elon Musk may want to consider such a facility before he gets too far down the road to establishing cities on Mars.
* Authors of Reproduction and the Early Development of Vertebrates in Space: Problems, Results, Opportunities: Alexandra Proshchina, Victoria Gulimova, Anastasia Kharlamova, Yuliya Krivova, Nadezhda Besova, Rustam Berdiev and Sergey Saveliev.
