AI generated image of a rotating space station in Earth orbit providing 1g of artificial gravity in the outer ring, with partial gravity in the inner ring and microgravity at the central hub. Credits: Microsoft Designer
SSP has been covering research on artificial gravity (AG) and its impact on space settlement for years. Many of these posts have focused on the Gravity Prescription for human physiology with particular interest in reproduction as humanity will want to ensure that our space settlements are biologically self sustaining (meaning we will want to have children and raise them there). Should we discover that gravity levels on the Moon or Mars are not conducive to couples raising healthy offspring, rotating space settlements with AG may be our only long term option. But there are many other benefits that spin gravity cities can provide for settlers. In a position paper published online last May in Acta Astronautica, gravity researcher Jack J.W.A. van Loon leads a team of European scientists in an exploration of the possibilities and advantages of rotating space stations providing AG. Van Loon founded and manages the Dutch Experiment Support Center (DESC), which provides user support for gravity related research. This study posits a toroidal orbital station large enough and rotating at a sufficient rate to provide 1g of AG in an outer ring, with an intermediate location for partial gravity laboratories and a nonrotating microgravity research facility in a central module.
From an engineering and human factors perspective, pre-flight training would be simplified because practice operations and procedure planning can be performed on the ground in Earth’s normal gravity. Microgravity environments present challenges for physical phenomena like fluid flow, condensation, and heat convection. Provision of a gravity vector eliminates many of these problems simplifying design and use of equipment. This would also reduce development time.
Life support systems utilizing plants to provide breathable air and nutritional sustenance function more naturally and would be less complex in a biosphere with AG. Since plants evolved on Earth to develop gravitropism with roots growing down relative to a gravity vector and shoots sprouting upward, there is no need to develop complex systems to function in microgravity for proper water and nutrient supply as was necessary for NASA’s Passive Nutrient Delivery System aboard the ISS. There would be easier application of hydroponics systems and vertical farming could be leveraged in habitats with AG while harvested fruits and vegetables can be easily rinsed prior to consumption.
With respect to operations, tasks are similar to normal ground based activities so again, less training would be required. Clutter would be reduced and tie downs for tools that tend to float away in microgravity are not necessary. Schedule management would be improved because there would be less time spent on the extra exercise necessary to counteract health problems induced by exposure to microgravity. Activities like showering and sleeping can be challenging in the absence of gravity, so AG would improve the quality of life in regard to these and other routines we take for granted on Earth.
As readers of SSP are aware, the well documented deleterious effects of exposure to microgravity would be mitigated for crews in an AG environment. Such exposure could preserve crew health by preventing losses in bone and muscle mass, cardiovascular deconditioning, weakening of the immune system, vision changes, cognitive degradation and many other spaceflight induced pathologies as documented in the paper’s references. For tourists or visiting researchers, disorientation and days-long adjustment to microgravity due to Space Adaption Syndrome would be prevented.
Safety would be enhanced as well. For instance, combustion processes and flames behave very differently in microgravity making fire suppression less well understood when compared to normal gravity, necessitating development of new safety procedures. Free floating liquids and tools tend to move around unrestricted causing hazards that could potentially short out electrical equipment. Microorganisms and mold could present a health hazard as humidity control is problematic without a gravity vector. Surgery and medical procedures have not been developed for weightless conditions, requiring specially designed equipment and processes. Liquids drawn from vials containing drugs behave differently in microgravity because of surface tension effects. As mentioned above, training for all activities and equipment designed for use in Earth-normal gravity can be performed ahead of time on the ground. Testing of flight hardware would be simplified as it would not need to be redesigned for use in microgravity. Finally, decades of health studies on astronauts in space under microgravity conditions have found that pathological microorganisms are less responsive to antibiotics while at the same time, become more virulent. AG could make these microbes respond as expected on Earth.
The space station proposed in this paper would include an inner ring housing hypogravity facilities where AG equivalent to levels of the Moon and Mars could be provided for investigators to study and tourists to experience. Mammalian reproduction could be studied in ethical clinical experiments to determine if conception, gestation, birth and maturation to adulthood is possible in lower gravity over multiple generations, starting with rodents and progressing to higher primates. The central module would provide a microgravity science center for zero-g basic research or manufacturing where scientists could perform experiments then return to the outer ring’s healthy 1g conditions.
The author’s budgetary analysis found that the cost of such a facility would be about 5% higher than a microgravity habitat due to increased mass for propulsion and supplementary structures, but the benefits outlined above would be an acceptable trade off enabling a better quality of life for tourists and permanent inhabitants. This concept could be the first step in validating health studies and living conditions in artificial gravity informing the design of larger free space settlements.
Artist rendering of a family living in a rotating free-space settlement based on the Kalpana Two design, with a length of 110m and diameter of 125m. Credits: Bryan Versteeg / Spacehabs.com
This post summarizes my upcoming talk for the Living in Space Track at ISDC 2024 taking place in Los Angeles May 23 – 26. The presentation is a distillation of several posts on the Gravity Prescription about which I’ve written over the years.
Lets start with a couple of basic definitions. First, what exactly is a space settlement? The National Space Society defined the term with much detail in an explainer by Dale L. Skran back in 2019. I’ve extracted this excerpt with bolded emphasis added:
Space Settlement is defined as:
“… a habitation in space or on a celestial body where families live on a permanent basis, and that engages in commercial activity which enables the settlement to grow over time, with the goal of becoming economically and biologically self-sustaining …”
The point here is that people will want to have children wherever their families put down roots in space communities. Yes, a “settlement” could be permanent and perhaps inhabited by adults that live out the rest of there lives there, such as in a retirement community. But these are not biologically self-sustaining in the sense that settlers have offspring that are conceived, born and raised there living out healthy lives over multiple generations.
Next we should explain what is meant by the Gravity Prescription (GRx). First coined by Dr. Jim Logan, the term refers to the minimum “dosing” of gravity (level and duration of exposure) to enable healthy conception, gestation, birth and normal, viable development to adulthood as a human being…over multiple generations. It should be noted that the GRx can be broken down into at least three components: the levels needed for pregnancy (conception through birth), early child development, and adulthood. The focus of this discussion is primarily on the GRx for reproduction.
We should also posit some basic assumptions. First, with the exception of the GRx, all challenges expected for establishment of deep space settlements can be solved with engineering solutions (e.g. radiation protection, life support, power generation, etc…). The one factor that cannot be easily changed impacting human physiology after millions of year of evolution on Earth is gravity. We may find it difficult or even impossible to stay “healthy enough” under hypogravity conditions on the Moon or Mars, assuming all other human factors are dealt with in habitat design.
Lets dive into what we know and don’t know about the GRx. Several decades of human spaceflight have produced an abundance of data on the deleterious effects of microgravity on human physiology, not the least of which are serious reduction in bone and muscle mass, ocular changes, and weakening of the immune system – there are many more. So we know microgravity is not good for human health after long stays. Clearly, having babies under these conditions would not be ethical or conducive for long term settlement.
The first studies carried out on mammalian reproduction in microgravity took place in the early 1990s aboard the Space Shuttle in a couple of experiments on STS-66 and STS-70. 10 pregnant rats were launched at midpregnancy (9 days and 11 days, respectively) on each flight and landed close to the (22 day) term. The rat pups were born 2 days after landing and histology of their brain tissue found spaceflight induced abnormalities in brain development in 70% of the offspring.
It was not until 2017 that the first mammalian study of rodents with artificial gravity was performed on the ISS. Although not focused on reproduction, the Japan Aerospace Exploration Agency (JAXA) performed a mouse experiment in their Multiple Artificial-gravity Research System (MARS) centrifuge comparing the impact of microgravity to 1g of spin gravity. The results provided the first experimental evidence that mice exposed to 1g of artificial gravity maintained the same bone density and muscle weight as mice in a ground control group while those in microgravity had significant reductions.
Diagram depicting an overview of the first JAXA Mouse Project in the MARS centrifuge with photos of the experiment on the ISS. Credits: Dai Shiba et al. / Nature. http://creativecommons.org/licenses/by/4.0/
In 2019 JAXA carried out a similar study in the MARS centrifuge adding lunar gravity levels to the mix. This study found that there were some benefits to the mice exposed to 1/6g in that Moon gravity helped mitigate muscle atrophy, but it did not prevent changes in muscle fiber or gene expression.
Just last year, a team led by Dr. Mary Bouxsein at Harvard Medical School conducted another adult mouse study on the MARS centrifuge comparing microgravity, .33g, .67g and 1g. They found that hind quarter muscle strength increased commensurate with the level artificial gravity concluding, not surprisingly, that spaceflight induced atrophy can be mitigated with centrifucation. The results were reported at the American Society for Gravitational and Space Research last November.
Returning to mammalian reproduction in space, an interesting result was reported last year in the journal Cell from an experiment by Japanese scientists at the University of Yamanashi carried out on the ISS in 2019. The team, headed up by Teruhiko Wakayama, devised a way to freeze mouse embryos post conception and launch them into space where they were thawed by astronauts and allowed to develop in microgravity. Control samples were cultured in 1g artificial gravity on the ISS and Earth normal gravity on the ground. The mouse embryos developed into blastocysts and showed evidence of cell differentiation/gene expression in microgravity after 4 days. The researchers claimed that the results indicated that “Mammals can thrive in space”. This conclusion really can’t be substantiated without further research.
Which brings us to several unknowns about reproduction in space. SSP has explored this topic in depth through an interview with Alex Layendecker, Director of the Astrosexological Research Institute. Yet to be studied in depth is (a) conception, including proper transport of a zygote through the fallopian tube to implantation in the uterus. Less gravity may increase the likelihood of ectopic pregnancy which is fatal for the fetus and could endanger the life of the mother; (b) full gestation through all stages of embryo development to birth; and (c) early child development and maturation to adulthood in hypogravity. All these stages of mammalian reproduction need to be validated through ethical clinical studies on rodents progressing to higher primate animal models before humans can know if having children in lower gravity conditions on the Moon or Mars will be healthy and sustainable over multiple generations.
AI generated image of an expectant mother with her developing fetus in Earth orbit after mammalian reproduction has been validated via higher animal models through all stages of pregnancy for a safe level of gravity. An appropriate level of radiation shielding would also be required and is not shown in this illustration. Credit: DALL-E-3
Some space advocates for communities on the Moon or Mars have downplayed the importance of determining the GRx for reproduction with the logic that a fetus in a woman’s uterus on Earth is in neutral buoyancy and thus is essentially weightless. Therefore, why does gravity matter? I discussed this question with Dr. Layendecker and he had the following observations paraphrased here: True, gravity may have less of an impact in the first trimester. But on the cellular level, cytoskeletal development and proper formation/organization of cells may be impacted from conception to birth. Gravity helps orient the baby for delivery in the last trimester and keeps the mother’s uterine muscles strong for contractions/movement of the baby through the birth canal. There are many unknowns on what level of gravity is sufficient for normal development from conception to adulthood.
Why does all this matter? Ethically determining the right level of gravity for healthy reproduction and child development will inform where families can safely settle space. The available surface gravities of bodies where we can establish communities in space cluster near Earth, Mars and Moon levels. These are our only GRx options on solar system bodies.
Gravity level clustering of solar system bodies available for space settlement. Credit: Joe Carroll
The problem is that we don’t yet know whether we can remain healthy enough on bodies with gravity equivalent to that on the Moon or Mars, so we can’t select realistic human destinations or formulate detailed plans until we acquire this knowledge. Of course we can always build rotating settlements in free space with artificial gravity equivalent to that on Earth. Understanding the importance of the GRx and determining its value could change the strategy of space development in terms of both engineering and policy decisions. The longer we delay, the higher the opportunity costs in terms of lost time from failure to act.
What are these opportunity cost lost opportunities? Clearly, at the top of Elon Musk’s list is “Plan B” for humanity, i.e. a second home in case of cataclysmic disaster such as climate change, nuclear war, etc. This drives his sense of urgency. From Gerard K. O’Neill’s vision in The High Frontier, virtually unlimited resources in space could end hunger and poverty, provide high quality living space for rapidly growing populations, achieve population control without war, famine, or dictatorships. And finally, increase freedom and the range of options for all people.
If humans can’t have babies in less than Earth’s gravity then the Moon and Mars may be a bust for long term (biologically sustainable) space settlement. There will be no biologically sustainable cities with millions of people on other worlds unless they can raise families there.
Spin gravity rotating space settlements providing 1g artificial gravity may be the only alternative. If Elon Musk knew that the people he wants to send to Mars can’t have children there, would he change his plans for a self-sustaining colony on that planet? Having and raising children is obviously important to him. As Walter Isaacson wrote in his recent biography of Musk, “He feared that declining birthrates were a threat to the long-term survival of human consciousness.”
So how could he determine the GRx quickly? One solution would be to fund a partial gravity facility in low Earth orbit to run ethical experiments on mammalian reproduction in hypogravity. Joe Carroll has been refining a proposal for such a facility, a dual dumbbell Moon/Mars low gravity laboratory which SSP has covered, that could also be marketed as a tourist destination. Spinning at 1.5 rpm, the station would be constructed from a combination of Starship payload-sized habitats tethered by airbeams allowing shirt sleeve access to different gravity levels. Visitors would be ferried to the facility in Dragon capsules and could experience 3 gravity levels with various tourist attractions. The concept would be faster, cheaper, safer and better than establishing equivalent bases on the Moon or Mars to quickly learn about the GRx. The facility would be tended by crews at both ends that live & collect health data for up to a year or more. And of course, ethical experiments on the GRx for mammalian reproduction would be carried out, first on rodents and then progressing to higher primates if successful.
Left: Conceptual illustration depicting a LEO Moon-Mars dumbbell partial gravity facility constructed from Starship payload-sized habitats tethered by airbeams and serviced by Dragon capsules. Rectangular solar arrays deploy by hanging at either end as spin is initiated via thrusters at Mars module. Center: Image of an inflated airbeam demonstration. Right: diagram of an airbeam stowed for transport and after deployment. Credit: Joe Carroll
What if these experiments determine that having children in lower gravity is not possible and our only path forward are free-space rotating settlements? Physics and human physiology require that they be large enough for settlers to tolerate a 1g spin rate to prevent disorientation. As originally envisioned by O’Neill, the diameter of his Island One space settlement would be about 500 meters.
Conceptual illustration of an Island One space settlement. The living space sphere is sized at about 500m in diameter. Credits: Rick Guidice / NASA
As originally proposed, these settlements would be located outside the Earth’s magnetic field at the L5 Earth-Moon Lagrange Point necessitating that they be shielded with enormous amounts of lunar regolith to protect occupants from radiation. Their construction requires significant technology development and infrastructure (e.g. mass drivers on the Moon, automated assembly in space, advances in robotics, power sources, etc…). Much of this will eventually be done anyway as space development progresses…however, knowing the GRx (if it is equal to 1g) may foster a sense of urgency.
Some may take the alternative viewpoint that if we know that Earth’s gravity works just fine we could proceed directly to free-space settlements if we could overcome the mass problem. This is the approach Al Globus and Tom Marotta took in their book The High Frontier: An Easier Way with Kalpana One, a 450m diameter cylindrical rotating free-space settlement located in equatorial low Earth orbit (ELEO) protected by our planet’s magnetic field, thereby reducing the mass significantly because there would be far less need for heavy radiation shielding.
Artist impression of Kalpana One rotating free-space settlement located in equatorial low Earth orbit. Credits: Bryan Versteeg / Spacehabs.com
Artist rendering of the inside of a rotating free-space settlement based on the Kalpana Two design, with a length of 110m and diameter of 125m. Credits: Bryan Versteeg / Spacehabs.com
Even though these communities would be lower mass, they will still require significant increases in launch rates to place the needed materials in LEO, especially near the equator. Offshore spaceports, like those under development by The Spaceport Company, could play a significant role in this infrastructure. Legislation providing financial incentives to municipalities to build spaceports would be helpful, such as The Secure U.S. Leadership in Space Act of 2024 introduced in Congress last month. The new law (not yet taken up in the Senate) would amend the IRS Code to allow spaceports to issue tax-exempt Muni bonds for infrastructure improvements.
Wouldn’t orbital debris present a hazard for settlements in ELEO? Definitely yes, and the National Space Society is shaping policy in this area. The best approach is to emphasize “light touch” regulatory reform on salvage rights, with protection and indemnity of the space industry to encourage recycling and debris removal. Joe Carroll has suggested a market-based approach that would impose parking fees for high value orbits, which would fund a bounty system for debris removal. This system would incentivize companies like CisLunar Industries, Neumann Space and Benchmark Space Systems, firms that are developing space-based processes to recycle orbital debris into useful commodities such as fuel and structural components.
Further down the road in technology development and deeper into space, advances in artificial intelligence and robotics will enable autonomous conversion of asteroids into rotating space settlements, as described by David Jensen in a paper uploaded to arXiv last year. This approach significantly reduces launch costs by leveraging in situ resource utilization. Initially, small numbers of “seed” tool maker robots are launched to a target asteroid along with supplemental “vitamins” of components like microprocessors that cannot be easily fabricated until technology progresses, to complete the machines. These robotic replicators use asteroid materials to make copies of themselves and other structural materials eventually building out a rotating space settlement. As the technology improves, the machines eventually become fully self-replicating, no longer requiring supplemental shipments from Earth.
Artist impression of a rotating space settlement constructed from asteroid materials. Credits: Bryan Versteeg, spacehabs.com
Leveraging AI to enable robots to build space settlements removes humans from the loop initially, eliminating risk to their health from exposure to radiation and microgravity. Send it the robot home builders – families then safely move in later. There are virtually unlimited supplies in the asteroid belt to provide feedstock to construct thousands of such communities.
Artist impression of the interior of Stanford Torus free-space settlement. Advances in artificial intelligence and robotics will enable autonomous self replicating machines that could build thousands of such communities from asteroid material. Credits: Don Davis / NASA
If rotating space settlements with Earth-normal gravity become the preferred choice for off-Earth communities, where would be the best location, the prime real estate of the solar system? Jim Logan has identified the perfect place with his Essential Seven Settlement Criteria.
Low Delta-V – enabling easy access with a minimum of energy
Lots of RESOURCES … obviously!
Little or No GRAVITY WELL – half way to anywhere in the solar system
At or Near Earth Normal GRAVITY for People, Plants and Animals - like what evolved on Earth
Natural Passive 24/7 RADIATION Protection – for healthy living
Permit Large Redundant Ecosystem(s) – for sustenance and life support
Staging Area for Exploration and Expansion (including frequent, recurrent launch windows)
Using this criteria, Logan identified Deimos, the outermost moon of Mars, as the ideal location. As discussed above, AI and robotic mining technology improvements will enable autonomous boring machines to drill a 15km long core through this body with a diameter around 500 meters – sized for an Island One space settlement to fit perfectly.
Conceptual illustration of a 500 meter wide by 15km long core bored through Deimos. Credit: Jim Logan
In fact, 11 Island One space colonies (minus the mirrors) strung end to end through this tunnel would provide sea level radiation protection and Earth normal artificial gravity for thousands of healthy settlers.
Left: Artist impression of an Island One space settlement. Credits: Rick Guidice / NASA. Right: To scale depiction of 11 Island One space settlements strung end-to-end in a cored out tunnel through Deimos providing sea level radiation protection and Earth normal artificial gravity. Credit: Jim Logan
In conclusion, the GRx for reproduction will inform where biologically self-sustaining healthy communities can be established in space. If we find that the GRx is equal to Earth’s normal level, free-space settlements with artificial gravity will be the safest and healthiness solution for humans to live and thrive throughout the solar system. The sooner we determined the GRx the better, for current plans for settling the Moon or Mars may need to be altered to consider rotating space colonies, which will require significant infrastructure development and regulatory reform. Alternatively, since we know Earth’s gravity works just fine, we may choose to skip determination of the GRx and start small with Kalpana in low Earth orbit. Eventually, artificial intelligence will enable safe, autonomous self-assembly of space settlements from asteroids. The interior of Deimos would be the perfect place to build safe, healthy, biologically self-sustaining space settlements for thousands of families to raise their children, establishing a beachhead from which to explore the rest of the solar system and preserve the light of human consciousness.
Update June 3, 2024: Here is a recording of my presentation on this topic at ISDC 2024.
AI generated image of an expectant mother with her developing fetus in Earth orbit after mammalian reproduction has been validated via higher animal models through all stages of pregnancy for a safe level of gravity. An appropriate level of radiation shielding would also be required and is not shown in this illustration. Credits:DALL∙E 3
We are one step closer to determining the gravity prescription for human reproduction in space. Okay, so we still don’t have the green light for having children at destinations in space with less than normal Earth gravity or higher radiation environments….yet. But a team of Japanese scientists report positive results after running an experiment aboard the International Space Station in 2019 that examined mouse embryos cultured in both microgravity and artificial gravity in space, then compared them to controls on Earth after a few days of development. The researchers published their results in a paper in iScience.
The researchers developed equipment and a protocol for freezing two-cell embryos after fertilization on the ground and launching them to the ISS where they were thawed then split into two groups, one allocated to growth in microgravity, the other treated with spin gravity to artificially simulate 1g. A control group remained on Earth. The procedure was designed to be executed by untrained astronauts. Cultured growth continued for 4 days after which the samples were preserved and refridgerated until they could be returned to Earth for analysis.
The samples were also monitored for radiation with a dosimeter and as expected aboard the ISS, were exposed to radiation levels higher then developing fetuses experience on the ground but far lower than those known to exist in deep space outside the Earth’s atmosphere and protective magnetic field. Still, this can be a “worst case” data point for radiation exposure to developing embryos as it is unlikely that pregnancy would be ethically sanctioned at higher levels.
Upon thawing by astronauts, the embryos were cultured through initial mitosis to eventual cell differentiation and blastocyst formation. A blastocyst is the multicellular structure of early embryonic development consisting of an an outer layer of cells called the trophectoderm surrounding a fluid-filled cavity in which an inner cell mass (ICM) called the embryoblast eventually develops into the embryo.
The study was concerned with how gravity may influence cell differentiation, the placement of the ICM within the blastocyst and if radiation effects gene expression in the these cells which will later develop into the fetus. Gene expression within the trophectoderm is also critical for proper development of the placenta.
The results were very promising as the data showed that there were no significant effects on early cell differentiation during embryo development and that proper gene expression manifested in microgravity when compared to 1g artificial and normal Earth gravity.
A human blastocyst with the inner cell mass at upper right. Credits: Wikipedia
A highlight of the paper implied that the results indicate that “Mammals can thrive in space.” It is too early to make such a bold statement with only this one study. It should be noted that this experiment only focuses on one early stage of embryo development. Conception in microgravity is not addressed and as pointed out by Alex Layendecker of the Astrosexological Research Institute, may have a whole other set of problems that raise ethical concerns as may the effects of lower gravity on later stages of gestation, in actual live birth and in early child development.
No matter how positive these recent results appear to be for early embryo development, as was determined by a landmark experiment on pregnant mice during the Shuttle era, we already have a data point on mammalian fetal development in later stages of gestation in microgravity: serious brain developmental issues were discovered in mice offspring born after exposure to these conditions. So mammalian reproduction in microgravity may start out relatively normally (assuming conception is successful) but appears to have problems in later stages, at least according to the limited data we have so far. On the bright side, the recent study found that 1g artificial gravity had no significant effects on embryo development.
Clearly more data is needed to determine which level of gravity will be sufficient for all stages of mammalian reproduction in space. Fortunately, SpaceBorn United is working on this very problem. They have plans for research into all stages of human reproduction in space to enable independent human settlements off Earth. SpaceBorn CEO Egbert Edelbroek in a recent appearance on The Space Show described upcoming missions later this decade that will study mammalian conception and embryo development using the company’s assisted reproductive technology in space (ARTIS). They have developed a space-embryo-incubator that will contain male and female mouse gametes, which upon launch into orbit, will initiate conception to create embryos for development in variable gravity levels. After 5-6 days the embryos would be cryogenically frozen for return to Earth where they would be inspected and if acceptable, placed in a natural womb for the rest of pregnancy and subsequent birth. If successful with mice the the company plans experiments with human stem cell embryos and eventually human gametes.
The gravity prescription for human reproduction in less than normal Earth gravity is still not known. But at least researchers are starting to gather data on this critical factor for long term biologically sustainable space settlement.
AI generated image of an amorous couple embracing in a space tourist destination. Credits: DALL-E
Last April, an international team of researchers published a green paper to solicit public consultation on the urgent need for dialogue concerning uncontrolled human conception which will be problematic for space tourism when it takes off in the near future. A coauthor on the paper, Alex Layendecker of the Florida based Astrosexological Research Institute (ASRI) studied the subject for his PhD thesis. Layendecker gave a talk at ISDC 2023 entitled Sex in Space in the Era of Space Tourism in which he emphasized the huge knowledge gap we have on mammalian conception, gestation and birth in the high radiation and lower gravity environments of outer space. Since humans evolved for millions of years in Earth’s gravity protected from radiation by our planet’s magnetic field and atmosphere, there is a significant risk of developmental abnormalities in offspring which could result in legal liability and potential impacts on commerce if conception occurs in space without consideration of the potential hazards. After his talk, I discussed these matters and the implications for space settlement with Alex who agreed to continue our discussion in an interview by email for this post.
SSP: Alex, it was a pleasure meeting you at ISDC and thank you for taking the time to answer my questions on this important topic. The green paper is attempting to foster discussion from relevant stakeholders on addressing “uncontrolled human conception”. Uncontrolled is defined in the paper as “…without societal approval for human conception – i.e. without regulatory approval from relevant bodies representing a broad societal consensus.” I am not aware of any regulatory authority on these matters at this time and there will likely be considerable challenges to obtain consensus across the space community before tourism becomes mainstream. The intent of the paper appears to be to help develop a framework for regulations (or guidelines) before space tourism takes off. Given how long it takes for regulations to be implemented and the challenges of international consensus, will there be enough time to implement sufficient controls before conception happens in space?
AL: Great question – short answer up front, no, I don’t believe any “controls” will be implemented before the first incidence of human conception in space, given the timelines we’re currently looking at. As you mentioned, regulations can take a long time to come into effect and you need to have a basis for establishing regulations/law – space law itself is still being developed. Our knowledge of reproduction in space is minimal at this stage, certainly not at the level it needs to be at this point of history. We’re also in virtually unexplored territory when it comes to mass space tourism – there have been space tourists in the past, Dennis Tito being the first “official” space tourist in history over 20 years ago – but all previous individuals that went into space for tourism purposes have done so while integrated into the crew, typically with very little privacy and a considerable amount of training. With mass access to space, we’ll soon have groups of individuals going up solely for vacation/leisure purposes, and you can be assured some of them will be engaging in sexual activity. While it would be absurd to try to implement or enforce laws preventing sexual activity in those environments, the dangers associated with potential conception still exist. What is critically needed at this point is a better collective understanding of those dangers, their mitigation, and for space companies to be able to provide those paying customers with enough information that informed consent can be established – space is inherently dangerous already, and people launching into space are briefed on that. They will need to be briefed on the dangers associated with conception in space as well, which could not only potentially threaten the life of the baby but also that of the mother, depending on the times and distances involved.
SSP: Will this be a government effort (since a green paper typically implies government sponsorship) or a self-imposed industry-wide trade association consensus approach like CONFERS? Or a combination?
AL: I think in the immediate sense, there will need to be a self-imposed industry consensus on establishing informed consent among space tourism customers. Sex and potential conception in space is currently a blind spot for would-be space tourism companies, because up to this point many of them haven’t considered the dangers it could pose to their customers, and corporate liability here is also an issue. It’s their responsibility to keep their passengers safe, and to inform them of any dangers to the max extent possible. I don’t necessarily see governments being able to implement or enforce any regulations in this regard, because regulating people doing what they want with their own bodies in the privacy of their own bedrooms typically doesn’t fare well over the long term. Where governments may get involved is if any medical situation develops to the point of needing rapid rescue, but Space Rescue capabilities is another topic.
SSP: Space tourism is likely to attract thrill seekers and risk-takers who are likely to have rebellious personalities with a reluctance to follow rules and regulations, let alone respect for societal norms. If this is the case, will pre-flight consultations on the risks of uncontrolled conception and legal waivers be sufficient to prevent risky behavior? Can the effectiveness of this approach be tested prior to implementation?
AL: Prevent risky behavior? Absolutely not. As you point out, these are folks who are intentionally undertaking an enormously risky endeavor in flying to space already, and at least in the early years, will be primarily comprised of your limits-pushing, boundary-breaking types. So they’re already about risk as individuals. However, legal waivers will of course be part of the whole operation, likely to include waivers around the risks of conception. Waivers or not, people are still going to engage in sex in space, and relatively soon, and if the individuals in question are capable of conception, the act itself brings that risk. Not to mention that there are individuals out there who will be vying for the title of “first couple to officially have sex in space,” despite speculation over the years that it could have occurred in the past. To be part of the first publicly declared coupling in outer space will land their names in history books. Now, there will be individuals who decide that they don’t want to deal with those risks after a thorough briefing on the potential dangers, but not everyone – probably not even a majority, knowing humans – will be deterred.
SSP: The paper highlights concerns about pregnancy in higher radiation and microgravity environments. From a space settlement perspective, radiation is less of a problem as there are engineering solutions (i.e. provision for adequate shielding) to address that issue. The bigger challenge will be pregnancies in microgravity, or in lower gravity on the Moon and Mars. The physiology of human fetus development in less than 1g is a big unknown. Some space advocates such as Robert Zubrin brush this off with the logic that a fetus in vivo on Earth is developing in essentially neutral buoyancy, and is therefore weightless anyway, so gestation in less than 1g probably won’t matter. Setting aside the issues associated with conception in lower gravity, if a woman can become pregnant in space, do you think this logic may be true for gestation or are there scientific studies and/or physiological arguments on the importance of Earth’s gravity in fetal development that refute this position?
AL: I’ve heard the neutral buoyancy argument before but it doesn’t address all the issues by a long shot. There is more neutral buoyancy during the first trimester of gestation but in the second and third gravity is very important, even just logistically speaking. Gravity helps the baby orient properly for delivery, and helps keep the mother’s uterine muscles strong enough to provide the necessary level of contractions to safely move the baby through the birth canal. On a more cellular level, cytoskeletal development is impacted by gravity, so even proper formation and organization of cells can be affected by microgravity throughout the span of gestation, from conception to birth. Gravity has a huge impact on postnatal development as well – in the small handful of NASA experiments we’ve conducted using mammalian young (baby rat and mouse pups), there were significant fatality rates among younger/less developed pups against ground control groups when exposed to microgravity during key postnatal phases. The youngest pups (5 days old) suffered a 90% mortality rate, and any of the survivors had significant developmental issues. So gravity is crucial not just to fetal development but to newborns and children as well, that much is evident from the data we do have.
SSP: Following up on your response, the Moon/Mars settlement advocates will say partial gravity levels on these worlds may be sufficiently higher than in microgravity to address the issues you mentioned – baby orientation, cytoskeletal development, cellular formation/organization, postnatal development – and a full 1g may not be needed for healthy reproduction. The mammalian studies you mentioned with detrimental postnatal development were in microgravity. We now have a data point at the lunar gravity level from JAXA with their long awaited results of a 2019 study on postnatal mice subjected to 1/6g partial gravity in a paper in Nature that was published last April. The good news is that 1/6g partial gravity prevents muscle atrophy in mice. The downside is that this level of artificial gravity cannot prevent changes in muscle fiber (myofiber) and gene modification induced by microgravity. There appears to be a threshold between 1/6g and Earth-normal gravity, yet to be determined, for skeletal muscle adaptation. Have you seen these results, can you comment on them and do you think they may rule out mammalian postnatal development in lunar gravity?
AL: With regard to the JAXA study, I think I’ve seen a short summary of preliminary results but haven’t gotten to read the full study yet. What I will comment for now is that there’s at least some promise in those results from a thousand foot view. While we still need to determine/set parameters for what we as a society/species consider medically/ethically acceptable for level of impact (obviously there was gene modification in the JAXA mice), there are clearly still some benefits to even lower levels of gravity.
SSP: With respect to risk mitigation and the paper’s recommended area of research: “Consolidation of existing knowledge about the early stages of human (and mammalian) reproduction in space environments and consideration of the ensuing risks to human progeny”, SSP has covered off-Earth reproduction and highlighted the need for ethical clinical studies in LEO to determine the gravity prescription (GRx) for mammalian (and eventually human) procreation. During our personal discussions at ISDC, you mentioned ASRI’splans for such studies in space. Can you elaborate on your vision for mammalian reproduction studies in variable gravity? What would be your experimental design and proposed timeline?
AL: Well, with regard to timelines, humanity as a whole is already behind, so we’ll need to move as quickly as we possibly can while still upholding safe medical and ethical standards. We’re approaching an inflection point where human conception in space is more probable to occur, and we still have vast data gaps that need to be filled on biological reproduction. I’d advocate that the best way to go about filling those gaps would be a systematic approach using mammalian test subjects to determine safe and ethically acceptable gravity parameters for reproduction. We already know a decent amount about the impacts of higher radiation levels on reproduction from data gathered on Earth, but with microgravity we’ve still got a long way to go, and we don’t know what the synergistic effects of microgravity and radiation are together either. With regard to experiments, NASA researchers have actually already designed extensive mammalian reproduction experiments with university partners, but those experiments haven’t been funded by the agency. There was a comprehensive experiment platform called MICEHAB (Multigenerational Independent Colony for Extraterrestrial Habitation, Autonomy and Behavior) that was proposed back in 2015, around the time I was completing my PhD dissertation. It would effectively be a robot-maintained mini space station that would study the microgravity and radiation effects on rodents in spaceflight over multiple generations, which of course requires sexual reproduction. That experiment alone would prove enormously beneficial to data collection efforts. It would be important to study said generations and physiological impacts at variable gravity levels as you mentioned – think the Moon, Mars, 0.5 Earth G, 0.75 Earth G and so on, so we could fine tune what level of impact we as a species are medically and ethically willing to accept in order to settle new worlds. With regard to ASRI’s experiment roadmap, our intent is to start with smaller, simpler experiments that will garner us more data on individual stages of reproduction first using live mice and rats, with the hope of eventually moving on to complex and comprehensive experiments like MICEHAB. Once we have a good plot of data over the course of many experiments, we can hopefully move on to primate relative studies to establish safe parameters for human trials. I anticipate the small mammal experiments alone will take at least five years were we to launch our first mission at this very moment – though speed is often dependent on level of funding, as happens with most science.
SSP: If contraceptives are recommended to prevent conception during space tourism voyages, the paper calls for validation of the efficacy of these methods in off-world environments. Do your plans for variable gravity experiments include such studies and how would you design the protocol?
AL: Well, the first important thing to remember is that contraceptives are known to fail occasionally on Earth – condoms can break (especially if used incorrectly), and even orally-taken birth control pills aren’t considered 100% effective. Currently ASRI doesn’t have plans for contraception studies because that’s further forward than we can reasonably forecast at this point. Frankly we need to establish medical parameters first regarding conception in space and know where the risk lines are before we implement birth control studies using humans. We have to take many small steps before we get there. Once we do have established limits for safe reproduction in space environments, we would look to operate any birth control studies within those parameters to determine efficacy. That way if the contraceptives do fail, we at least know the resulting pregnancy has a reasonable chance of success.
SSP: Should experiments on mammalian reproduction in variable gravity determine that fetal developmental or health issues arise after conception and gestation in less than 1g, do you think this may lead to a significant shift in the long-term strategy for space settlement (e.g. toward O’Neill type artificial gravity space settlements) if children are to be born and raised in space?
AL: I certainly think so. There’s a lot at stake here. If we can’t safely birth and grow new generations of humans at a Martian gravity level (0.38 Earth G), then we’ve largely lost Mars as a destination for permanent multigenerational settlement. Fully grown adults can live and work down on the planet itself, but we’d need to come up with an alternate nearby solution for pregnant mothers and children growing up to certain age. From an engineering perspective, artificial gravity space settlements like an O’Neill cylinder make the most sense to me personally, so long as there’s Earth-level radiation shielding and gravity, and you can recreate Earth-like environments within those structures. During our conversation at ISDC I referred to it as an “Orbital Incubator” concept, though I’m of course not the first person to ever discuss something like that.
SSP: I appreciate you sharing your PhD Thesis with me. In that work you developed the Reproduction and Development in Off-Earth Environments (RADIO-EE) Scale to provide a metric that could help future researchers identify potential issues/threats to human reproduction in space environments, i.e. microgravity and radiation. Respecting your request that the images of the metric not be published at this time, qualitatively, the scale plots the different phases of reproduction, fetal development, live birth and beyond against levels of gravity or radiation in outer space environments encompassing the range from microgravity all the way up to 1g (and even higher). The scale displays green, amber, and red areas mapping safe, cautionary, and forbidden zones, respectively, dependent on location (e.g. Moon, Mars, free space, etc.). When I originally read your thesis I thought you included both gravity and radiation on the same chart but after our discussions I understand that they would have to be separated out. I also acknowledge that we have no data at this time and the metric is a work in process to be filled in as experiments are performed in space. Have you consideredusing three dimensions (gravity on x-axis, radiation on the y-axis, viability on the z-axis) and create a surface function for viability. Does that make sense?
AL: I’m totally with you on the 3D model scale (I’ve always thought of it like navigating a “tunnel” made up of green data points to reach the end of the reproductive cycle safely). The scale was originally envisioned as separate graphs for Microgravity/Hypergravity and Radiation, but obviously we couldn’t combine those in 2D because those two different factors can vary wildly depending on where you’re physically located in the solar system/outer space in general. So the best answer is to effectively plot green, amber, and red “zones” on each chart (again based on location), then make sure that wherever we’re trying to grow/raise offspring (of any Earth species) we’re keeping our expectant mothers and children in double-green zones (for both gravity, and radiation). Now the third axis would actually be time (i.e. what point are you at in the reproductive cycle), with viability being determined by where all three axes meet in a green/amber/red zone.
I’d like to thank Alex for this informative discussion and look forward to further updates as his research progresses. We urgently need his insights to inform ethical policies and practices regarding reproduction for the space tourism industry in the short term, and eventually for having and raising healthy children wherever we decide to establish space settlements. Readers can listen to Alex describe his research live and talk to him in person when he appears on The Space Show currently scheduled for August 27.
